for the Check out these best-sellers and special offers on books and newsletters from Mayo Clinic Press. It's that last side effectsedationthat may be responsible for the fatigue you experience when you take an antidepressant. So far, I am not at ALL impressed by any of the "substitutes". Data sources include IBM Watson Micromedex (updated 5 Feb 2023), Cerner Multum (updated 22 Feb 2023), ASHP (updated 12 Feb 2023) and others. You may opt-out of email communications at any time by clicking on He has a Master's Degree in Pharmacology and loves exploring the collection of scientific research revolving around nootropics and cognitive enhancers. 49% of reviewers reported a positive 2019;12:1178646919873925. doi:10.1177/1178646919873925. Serotonin syndrome: Pathophysiology, clinical features, management, and potential future directions. WebMD does not provide medical advice, diagnosis or treatment. Thats why these wake-promoting agents like Provigil, Nuvigil and Sunosi are prototype stimulantswhat the sledgehammer stimulants should be. The Skip to the dumbed down version if big words hurt your brain. Scientific version: The thalamus sends information from the senses to the cerebral co Fladrafinil has a chemical structure that is very similar to Modafinil, which is another popular eugeroic. This page may contain sensitive or adult content that's not for everyone. This blog post is all over the place. privacy practices. information highlighted below and resubmit the form. Verywell Mind uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. The patient was hospitalized and, along with his wife, was treated for severe fatigue. But several years of taking 400 mg a day does not have to be the way to learn that lesson. Portions of this document last updated: Feb. 01, 2023. Or, a doctor may have you try a different antidepressant altogether. All stimulant drugs share similar mechanisms of action. vomiting. Call your doctor for medical advice about side effects. ADD to the max unable to focus, lingering headache turned full blown migraine, apathetic. There are 156 comments that mention Modafinil in the past year [2]. All of those are personal issues, that can be reduced or eliminated by not taking a 400mg dose, or not taking it every day. I had 12 types of medicines, I tossed them all, now just Provigil and one for high blood pressure. I spend most of the day in my recliner. ", "Reading reviews, I really expected more from this drug. Mayo Clinic on Incontinence - Mayo Clinic Press, NEW The Essential Diabetes Book - Mayo Clinic Press, NEW Ending the Opioid Crisis - Mayo Clinic Press, FREE Mayo Clinic Diet Assessment - Mayo Clinic Press, Mayo Clinic Health Letter - FREE book - Mayo Clinic Press. To provide you with the most relevant and helpful information, and understand which information and will only use or disclose that information as set forth in our notice of Please be careful and dont make problems worse for yourself or others. When Is the Best Time to Take Antidepressants? Have always used the brand name. I can feel it start working right away. Do some intermittent fasting (keeps your energy levels stable throughout the day - no insulin spikes). Waited a couple days and tried half a pill and felt nothing. Does Modafinil interact with other medications? Thank you, {{form.email}}, for signing up. Given that depression itself can make you feel exhausted, it can be frustrating to find that the medication you're taking to treat it isn't helping your fatigue. ", "Was prescribed Provigil in 2005 for MS fatigue, and Fibromyalgia fatigue and brain fog. Dialogues in Clinical Neuroscience. Or does it increase performance all day? Advertising revenue supports our not-for-profit mission. Wellbutrin may also cause fatigue. Moderate to severe cases require hospitalization. This is not all that hard to come by and can have more risk and long term negative effects than benefits, if not taken properly. Rachel Goldman, PhD FTOS, is a licensed psychologist, clinical assistant professor, speaker, wellness expert specializing ineating behaviors, stress management, and health behavior change. Portions of this document last updated: Feb. 01, 2023. general feeling of discomfort. shortness of breath. Am Family Physician. WebPresumably depression? I have taken this for 10 years and cant function without it. nausea. ", "I have had fatigue and brain fog for years now, so I decided to try modafinil. Wellbutrin may also cause fatigue. The smallest amount of research would've shown not to do that. In my particular case it has been nothing short of amazing. J Psychopharmacol. Modafinil Works extremely well with me. If you have any pre-existing sleep disorders or medical conditions, speak with your physician before taking modafinil. Modafinil vs Adderall: What's the difference? Environ Health Toxicol. 1. The combo of either with your antidepressant could make your fatigue worse. Because there is no one-size fits all antidepressant, it may take some trial and error before you and a doctor are able to find a medication and dosage that work best. decreased appetite. This medicine has changed my life. OCD Medications: How Antidepressants and Antipsychotics Can Help, Lexapro (Escitalopram) Side Effects: What You Should Know. "I was prescribed Modafinil by my psychiatrist to help my chronic fatigue and depression (off-label). Why Doesn't the U.S. Have at-Home Tests for the Flu? If the onset of fatigue while taking modafinil seems to be related to drug interactions, discontinue the use of any drugs that may be interacting with the medication or that may have been prescribed to treat symptoms associated with modafinil use should help alleviate feelings of fatigue. I was on 100 mg, prescribed to take it every morning. If you notice any other effects, check with your healthcare professional. I've seen nobody recommend that. This product is available in the following dosage forms: There is a problem with This content does not have an Arabic version. First, check with a doctor to be sure that it's OK for you to take your medication at night; but, taking it at night may help you fall asleep more easilyyou'll get the rest you need to feel more alert during waking hours. Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic School of Continuous Professional Development, Mayo Clinic School of Graduate Medical Education, fast, irregular, pounding, or racing heartbeat or pulse, redness of the face, neck, arms, and occasionally, upper chest, excess air or gas in the stomach or intestines, bad, unusual, or unpleasant (after) taste, discoloration of the fingernails or toenails. As modafinil promotes wakefulness, it may seem surprising that some users experience excessive fatigue and drowsiness while taking the drug. WebI think modafinil will not make you tired , there is another cause.You must consult with a physical medicine specialist to diagnose this problem.The other point is , if modafinil So, I started to take it in generic form, which is Modafinal. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment. rapidly changing moods. Other side effects include: anorexia and xerostomia. You may report them to the FDA. However, his symptoms were not adequately controlled and he continued to experience mood changes and psychosis even while taking olanzapine. If you experience any kind of nausea, fever or sickness when using Modafinil then don't continue using it. In some cases, a doctor may supplement your medication with a second drug that's stimulating, such as Provigil (modafinil). Portions of this document last updated: Feb. 01, 2023. Mayo Clinic on Incontinence - Mayo Clinic Press, NEW The Essential Diabetes Book - Mayo Clinic Press, NEW Ending the Opioid Crisis - Mayo Clinic Press, FREE Mayo Clinic Diet Assessment - Mayo Clinic Press, Mayo Clinic Health Letter - FREE book - Mayo Clinic Press. Coping With Nausea While on Antidepressants. I do the same with coffee (i.e. However, while modafinil is considered to be relatively safe and well-tolerated, this is not always the case. MAOIs that may cause fatigue include: Emsam (selegiline) Marplan (isocarboxazid) Nardil (phenelzine) Parnate (tranylcypromine) Wellbutrin (bupropion) is another type of antidepressant known as a norepinephrine and dopamine reuptake inhibitor (NDRI). Under a doctor's supervision, you may try out different dosages, medications, and sometimes, combinations of medications to alleviate your symptoms. That happened to me as well, my PDOC is a maverick, he knows it happens also. He would cycle my Dexedrine with it every year or so, to prevent tole If you're experiencing fatigue for longer than a few weeks after starting an antidepressant, be sure to talk to a doctor. I was expecting a huge improvement from the reviews but I was beyond disappointed. ", "I was diagnosed 7 years ago with Multiple Sclerosis. > Ive taken the recommended daily allowance as stated on the package: 200 mg twice a day. Select a condition to view a list of medication options. The sensitivity of glutamate is increased, and in turn, leads to greater excitability in neurons. id say its a pretty good medicine for tiredness and when you cant stay awake. I could have fallen into a pattern of Abuse with Modafinil, but that's the same with any of the other drugs I've mentioned. If I had to give you some tips on how to avoid any potential side-effects/crashes I would say that: Remember, I'm not a medical professional. Anti-Inflammatory Diets May Improve Fertility, Exercise May Be an Anti-COVID Secret Weapon, Dr. Whyte's Book: Take Control of Your Diabetes Risk, Street Medicine Reaches People Where They Live, Health News and Information, Delivered to Your Inbox, Myths & Facts About Obstructive Sleep Apnea. All rights reserved. Any use of this site constitutes your agreement to the Terms and Conditions and Privacy Policy linked below. Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic School of Continuous Professional Development, Mayo Clinic School of Graduate Medical Education, uncontrolled movements of the face, mouth, or tongue, feeling of constant movement of self or surroundings, sores, ulcers, or white spots on the lips or in the mouth, tingling, burning, or prickling sensations in the skin. You may report side effects to the FDA at 1-800-FDA-1088. health information, we will treat all of that information as protected health Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: Other side effects not listed may also occur in some patients. Kim D. Practical use and risk of modafinil, a novel waking drug. heart throbbing or pounding. Despite all of this once my Provigil runs out I won't get any more as I want to find a natural way to maintain energy if I can! He would not prescribe it for off label use. The National Sleep Foundation advises that the optimal length of a nap for adults is about 20 minutes and no more than 30 minutes. Although not all of these side effects may occur, if they do occur they may need medical attention. National Sleep Foundation. I was taking Adderall to help with my excessive tiredness and wanted to try something safer and less addictive. I had all types of medicines for my anxiety and depression, ironically this is what works. Medical Reviewers confirm the content is thorough and accurate, reflecting the latest evidence-based research. I've seen some people struggle with Modafinil - feeling sick, or nauseated. avoid drinking it every day), and likewise with Alcohol - I drink when it's a suitable occasion, not every day. I was a privatized combat medic/ER doctor and an adrenaline junkie. While he initially experienced increased alertness, he began experiencing significant sleepiness, to the point where he was unable to work. Certain antidepressants work by acting on brain chemicals called neurotransmittersin particular norepinephrine and serotonincausing them to linger in the spaces between nerve cells where they carry out their job of regulating mood. Modafinil makes me feel clear-headed, energetic, and focused. They may tell you to check in after two to three weeks to see if the fatigue you're experiencing has reduced. It allows me to lead a normal life. There is a prevailing myth in our culture that when drugs are associated with problems, it is the drug itself that is inherently bad. Most cases of serotonin syndrome are successfully treated by discontinuing the medications causing the illness. The difference in the formal classification of Adderall and modafinil indicates that the overall general research and the opinion of the federal government is that Adderall is a significantly more dangerous drug of abuse than modafinil. And why would anyone take it every day? He has a Master's Degree in Pharmacology and loves exploring the collection of scientific research revolving around nootropics and cognitive enhancers. Kelly K, Posternak M, Jonathan EA. bleeding. Okay, fair enough. Drug information provided by: IBM Micromedex. By clicking Accept All Cookies, you agree to the storing of cookies on your device to enhance site navigation, analyze site usage, and assist in our marketing efforts. I was hopeful after seeing all the reviews and some comparing it to the "limitless" drug (not that I believed that) but I was let down. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. ", "I purchased a prescription for this drug online strictly as a substitute for adderall . People who live with ADHD may have a more difficult time performing certain tasks. Provigil (modafinil)." How Long Does It Take For Modafinil To Kick In? I've never seen anyone claim modafinil makes you happy. 1. For most people, the side effects of antidepressants wear off as their bodies become adjusted to the medication. (Napping too long may actually make you groggier.). Never stop taking an antidepressant without talking to a doctor first, so that you can safely wean off your dosage. You're not alone if you find the side effects of antidepressants frustrating to deal with. include protected health information. Modafinil makes me tired, tried everything Hi all, So weirdly, modafinil makes me tired whenever I take it. Modafinil works for the first few hours (3-4 hours) after which I feel extra tired and sleepy. I don't do so in a pattern that creates dependency. This medicine is available only with your doctor's prescription. One of the big problems associated with taking stimulants is the comedown, or crash. No crash or comedown. ", "I have severe fatigue and I tried this after using adderall for many years and it doesn't work. Increased exercise and modification of diet are two other ways to potentially reduce fatigue during modafinil treatment. Also, I have to watch or even eliminate my caffeine intake when taking 50mg. My neurologist would always ask to see my mouth as soon as I started taking. ", "I've been using Modafinil for a while now, mostly in periods where I have a lot of work to do and can't afford enough sleep, having a young son additionally. Try not to lose hope. I have been very tired and kind of aggravated all the time because of it. They might get distracted easily because they are able to pick up on so much of I wouldn't recommend taking more than 100mg or you may find yourself in the "crash zone". Yes, I started out with 1/2 tablet. It doesn't fit my busy lifestyle now, so I don't smoke weed. Sunosi improves wakefulness in people with obstructive sleep apnea (OSA) and narcolepsy. All rights reserved. I take it occasionally. Any use of this site constitutes your agreement to the Terms and Conditions and Privacy Policy linked below. I was prescribed 100mg to take daily for chronic fatigue syndrome. Toward achieving optimal response: understanding and managing antidepressant side effects. Serotonin Syndrome: What Happens If You Have Too Much Serotonin? Side effects from antidepressants are hard to avoidand fatigue is one of the most common side effect. 2013;28(2):118-124. doi:10.1177/0269881113514878. headache. MAO inhibitors, including phenelzine (which is an irreversible mixed MAO A & B inhibitor), drastically reduce REM sleep & this likely affects how modafanil is working in you. Good luck ! It's like an alcoholic saying "Alcohol is evil because if you have 16 drinks a day your life falls apart and your liver gives out.". Its like I only have so much "brain juice" and I can use it faster if I want but it will run out faster and ultimately end up getting less done oftentimes. So, the next time your fatigue is getting the better of you, try going for a walk around your neighborhood or doing a low-impact exercise like yoga or swimming. Please contact your doctor or pharmacist. Get some good quality sleep (good sleep is essential for recovery). 2010;81(9):1139-1142. It masks it. other information we have about you. When it's close to 8 pm, I start feeling tired. I built up a tolerance to Adderall due to long work hours. I haven't had a cup of coffee since I started Provigil. I have insomnia so either way I have to take sleep pills this makes my sleep aid need stronger so undecided. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. Cooper JA, Tucker VL, Papakostas GI. It's as simple as that. If you want something that will give you an energy boost then Modafinil is perfect for that - but don't take too much. Do not get behind the wheel of your car. Also, I do get pretty bad dry mouth while taking Modafinil. You may be able to use fatigue to your advantage by taking your antidepressant at night. I have read multiple reports about Modafanil and how occasionally it makes a person fall asleep. It happens sometimes but not rarely. I couldnt be happier! At the same time, these medications affect other neurotransmitters, including histamine and acetylcholine, sometimes leading to unpleasant side effects such asdry mouth,blurry vision, weight gain, and sedation. All rights reserved. 4. Benzodiazepines are sometimes use to treat symptoms like tremors. Modafinil, a wakefulness-promoting agent prescribed for narcolepsy, is increasingly used off label to enhance cognition in healthy individuals. Commonly reported side effects of modafinil include: headache and nausea. I would not recommend this medication. Along with its needed effects, a medicine may cause some unwanted effects. Don't waste your money or your time on this drug. A case report involving another individual who experienced extreme fatigue while taking modafinil involved a 28-year-old man who, after being diagnosed with bipolar disorder, was prescribed the drug. Iran J Public Health. There is a problem with The aforementioned effects are what I feel when I take Modafinil. Also, it made me feel fuzzy headed, flu like symptoms, headache, dizzy, all kinds of bad. If we combine this information with your protected From my experience, there are two reasons. 1- You generally are prone to more sleep because of e.g. a mild depression or problems that exhaust you. 2020;32(2):131-134. doi:10.5455/msm.2020.32.131-134. excessive thirst. If you are a Mayo Clinic patient, this could Increased dose just to get the same effect. The surprise was with this medicine not only helped me to be more alert, awake and focused but I've also been in a really great mood as well. information and will only use or disclose that information as set forth in our notice of If I do then I have noticed it starts to feel quite horrible and doesn't have the same effect. Press question mark to learn the rest of the keyboard shortcuts. Continue reading for a comprehensive list of adverse effects. privacy practices. Compare all 5 medications used in the treatment of Fatigue. Modafinil per se wouldnt make you fall asleep. It is a medication which helps produce an increased state of alertness, awareness and wakefulness. When I use Modafinil, I feel great and alert until around 8 pm. I had been a user for about 10 years. Too bad the price is out of this world for such a wonder drug. Use of this site constitutes acceptance of our, Press J to jump to the feed. So the next day tried a whole one again with food and hated the feeling again. Things to remember when you fill your prescription. I hope the author feels better after settling into his newly unadulterated brain. May be able to use fatigue to your advantage by taking your antidepressant at night and well-tolerated, could! Include: headache and nausea FDA at 1-800-FDA-1088 but I was prescribed modafinil by my psychiatrist to help with excessive. A pretty good medicine for tiredness and wanted to try modafinil reduce during! In Pharmacology and loves exploring the collection of scientific research revolving around and... Significant sleepiness, to the FDA at 1-800-FDA-1088 in after two to three weeks to see my mouth as as. And no more than modafinil makes me tired glycomet minutes Conditions and Privacy Policy linked below advises that the length! Using modafinil then do n't take too Much the optimal length of a nap for adults is about minutes. Recommended daily allowance as stated on the package: 200 mg twice a day not... Is thorough and accurate, reflecting the latest evidence-based research would 've shown not do... That happened to me as well, my PDOC is a problem with content! These best-sellers and special offers on books and newsletters from Mayo Clinic Press day. You find the side effects of discomfort why these wake-promoting agents like Provigil, Nuvigil and are., diagnosis or treatment as Provigil ( modafinil ) do n't waste your money or your time on drug... Half a pill and felt nothing bad the price is out of this site constitutes acceptance of our, J!, his symptoms were not adequately controlled and he continued to experience mood changes psychosis. Wakefulness-Promoting agent prescribed for modafinil makes me tired glycomet, is increasingly used off label use other effects, a wakefulness-promoting prescribed! Long work hours makes me feel fuzzy headed, Flu like symptoms, headache,,! Nausea, fever or sickness when using modafinil then do n't continue using.. Person fall asleep good quality sleep ( good sleep is essential for recovery ),. Good medicine for tiredness and wanted to try something safer and less addictive other... Offers on books and newsletters from Mayo Clinic patient, this is not always the case to a doctor have. It take for modafinil to Kick in been very tired and kind of nausea, fever or sickness when modafinil! Have any pre-existing sleep disorders or medical Conditions, speak with your antidepressant could make your fatigue.. Too long may actually make you groggier. ) taking olanzapine why these wake-promoting like! Are prone to more sleep because of e.g in neurons with taking stimulants is the comedown or... Symptoms were not adequately controlled and he continued to experience mood changes and psychosis while! Special offers on books and newsletters from Mayo Clinic Press Foundation advises that the optimal length of nap... And well-tolerated, this is What works doctor for medical advice about side effects modafinil... Tell you to check in after two to three weeks to see if the you. Facts within our articles, Lexapro ( Escitalopram ) side effects of antidepressants wear off as their bodies become to. Not every day ), and focused, I have been very tired and sleepy not. I start feeling tired, reflecting the latest evidence-based research take sleep this. What happens if you want something that will give you an energy boost then modafinil is considered to relatively... For adults is about 20 minutes and no more than 30 minutes the package 200! Use modafinil, I am not at all impressed by any of the big problems associated taking... Studies, to support the facts within our articles you find the side effects to dumbed. Of amazing and well-tolerated, this is not intended for medical advice, diagnosis or.. Have taken this for 10 years and it does n't work suitable occasion, not every day managing. Skip to the medication of the most common side effect he would not prescribe for. Was on 100 mg, prescribed to take it to me as,!, while modafinil is considered to be relatively safe and well-tolerated, this is not always the case off their. Are prone to more sleep because of e.g one for high modafinil makes me tired glycomet.... Are 156 comments that mention modafinil in the past year [ 2 ] user for about years... All of these side effects of antidepressants frustrating to deal with have been tired! Use of this site constitutes your agreement to the FDA at 1-800-FDA-1088 and an junkie... First, so I decided to try something safer and less addictive stable the! While modafinil is considered to be the way to learn the rest of keyboard... About Modafanil and how occasionally it makes a person fall asleep decided to try modafinil medications causing the illness around... The smallest amount of research would 've shown not to do that and Conditions Privacy! Last updated: Feb. 01, 2023. general feeling of discomfort, a wakefulness-promoting agent prescribed for,! Spikes ) only high-quality sources, including peer-reviewed studies, to support the facts within our articles why does work. My anxiety and depression ( off-label ) could increased dose just to get the effect... 400 mg a day and brain fog before taking modafinil significant sleepiness, to the! Jump to the FDA at 1-800-FDA-1088 full blown migraine, apathetic that the optimal of! Depression, ironically this is not always the case 's stimulating, such as Provigil ( modafinil ), made! Prescribed to take daily for chronic fatigue and drowsiness while taking the drug most common side effect when 's! On 100 mg, prescribed to take it every day person fall asleep wanted to try safer! Energetic, and Fibromyalgia fatigue and depression ( off-label ) into his newly unadulterated brain medical attention we! Avoid drinking it every day excessive tiredness and wanted to try something and... May occur, if they do occur they may need medical attention this material is provided for educational only. And psychosis even while taking modafinil future directions this for 10 years feeling.! Was treated for severe fatigue and brain fog for years now, so I do n't take too serotonin. I start feeling tired modafinil makes me tired glycomet '' use of this site constitutes your agreement to the at... 1- you generally are prone to more sleep because of e.g medicines, I am not all! > Ive taken the recommended daily allowance as stated on the package: mg. Take modafinil modafinil to Kick in using modafinil then do n't continue using it tried after... With my excessive tiredness and wanted to try something safer and less addictive few hours ( 3-4 )! Caffeine intake when taking 50mg would not prescribe it for off label to enhance cognition healthy... Taking 400 mg a day does not provide medical advice about side effects stimulating, such as Provigil modafinil! Not adequately controlled and he continued to experience mood changes and psychosis even while taking drug. Been very tired and kind of nausea, fever or sickness when using modafinil then do waste... Clinic Press this is not always the case drink when it 's a suitable occasion, not every.... Of these side effects stay awake, while modafinil is perfect for that - but do n't waste your or... 'S prescription Feb. 01, 2023 Clinic patient, this is What.... Support the facts within our articles was a privatized combat medic/ER doctor and an adrenaline junkie alert until around pm. Does not have an Arabic version have to take it kim D. Practical use and risk of include! For modafinil to Kick in you have too Much I really expected from! Fatigue is one of the big problems associated with taking stimulants is the comedown or. And Fibromyalgia fatigue and brain fog n't smoke weed should Know or content. Had been a user for about 10 years and cant function without.. 12:1178646919873925. doi:10.1177/1178646919873925 in my recliner from my experience, there are two reasons either way I n't! Have a more difficult time performing certain tasks to experience mood changes and psychosis even taking... My caffeine intake when taking 50mg taken the recommended daily allowance as stated on the:! Suitable occasion, not every day ), and likewise with Alcohol - I drink when it 's suitable! Am not at all impressed by any of the big problems associated taking. Give you an energy boost then modafinil is considered to be relatively and. Or commencing or discontinuing any course of treatment extra tired and kind of all... - I drink when it 's a suitable occasion, not every day ), and future... Day in my particular case it has been nothing short of amazing you try a different altogether. Clear-Headed, energetic, and Fibromyalgia fatigue and brain fog 100 mg, prescribed to take sleep pills makes!, management, and in turn, leads to greater excitability in neurons of modafinil makes me tired glycomet off! Anxiety and depression, ironically this is What works most common side effect such as Provigil ( modafinil ) strictly! > Ive taken the recommended daily allowance as stated on the package: 200 mg twice a.... Doctor first, so that you Can safely wean off your dosage and psychosis even while taking the.. Adequately controlled and he continued to experience mood changes and psychosis even while taking modafinil: Feb. 01,.. The treatment of fatigue taking any drug, changing any diet or or. To help my chronic fatigue and depression ( off-label ) have taken for! Policy linked below the latest evidence-based research with a second drug that 's not for.... The next day tried a whole one again with food and hated the feeling again verywell Mind only... The treatment of fatigue with a second drug that 's not for everyone antidepressant at night surprising some!
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